Welcome to the my personal evolutionary genomics (myPEG) web user interface. From here you can access the following evolutionary (E-) tools developed by the Kumar Lab:
A web-resource developed to enable the query and exploration of the information contained in the GRASP2 database alongside evolutionary information which we have added for each single nucleotide polymorphism (SNP). This evolutionary information can be used to prioritize SNPs with a greater likelihood of bona fide and reproducible genetic disease associations.
A web-resource developed to provide phenotype-associated SNP ranking measurements that integrate evolutionary conservation scores and association P-values.
A web-resource that offers access to evolutionary diagnosis predictions for human exome variants and utilizes an efficient predictive statistical model that draws from fundamental evolutionary properties of amino acid changes.
A web-resource developed to enable access to neutral evolutionary probabilities of each possible amino acid residue at a given human protein position. This evolutionary information can be used to identify SNPs with a greater likelihood of functional impact or neutrality.
A web-resource developed to enable access to candidate adaptive polymorphisms (caps) in human exomes that have been discovered with a new integrated method that uses phylogenomics and population genomics (Kumar et al., in preparation).